Covid-19：米ギリアド・remdesivir、有効性示さず：WHOの治験結果（動画）：
Massive WHO remdesivir study suggests no Covid-19 benefit：
大规模的WHO remdesivir研究表明Covid-19无益处
米ギリアド・remdesivir：
2020年5月、米ギリアド・remdesivirに、米食品医薬品局の緊急使用許可が、与えられました。
しかし、WHOの治験では、有効な治験結果が、得られていません。
WHOの治験結果：
—WHOの治験結果で、「Covid-19患者に、有効でないでないこと」が判明しました。
—WHOの治験は、30か国の11,200人以上を対象に実施されました。
—世界保健機関の連帯試験の結果が、それを示しています。
Remdesivir：
It was published online Thursday on the preprint server medRxiv, meaning it has not been peer-reviewed.
Remdesivir wasn’t the only treatment given to patients in the trial.
The trial found that overall,
remdesivir did not reduce deaths and did not help patients with severe Covid-19 get out of the hospital more quickly.
hydroxychloroquine
lopinavir
interferon
Some received hydroxychloroquine (which has since been shown to be ineffective in treating Covid-19), lopinavir (an antiviral used in HIV treatment) and interferon (another antiviral).
Some received a combination of the drugs. Others got just one. Still others received no treatment.
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results edRxiv
Abstract
BACKGROUND WHO expert groups recommended mortality trials in hospitalized COVID-19 of four re-purposed antiviral drugs.
METHODS
Study drugs were
Remdesivir,
Hydroxychloroquine,
Lopinavir (fixed-dose combination with Ritonavir)
Interferon-β1a (mainly subcutaneous; initially with Lopinavir, later not).COVID-19 inpatients
were randomized equally between whichever study drugs were locally available and open control (up to 5 options: 4 active and local standard-of-care).
The intent-to-treat primary analyses
are of in-hospital mortality in the 4 pairwise comparisons of each study drug vs its controls (concurrently allocated the same management without that drug, despite availability).
Kaplan-Meier 28-day risks are unstratified; log-rank death rate ratios (RRs) are stratified for age and ventilation at entry.
RESULTS In 405 hospitals in 30 countries
11,266 adults were randomized, with 2750 allocated Remdesivir,
954 Hydroxychloroquine,
1411 Lopinavir,
651 Interferon plus Lopinavir,
1412 only Interferon,
4088 no study drug.
Compliance was 94-96% midway through treatment, with 2-6% crossover.
1253 deaths were reported (at median day 8, IQR 4-14).
Kaplan-Meier 28-day mortality was 12% (39% if already ventilated at randomization, 10% otherwise).
Death rate ratios (with 95% CIs and numbers dead/randomized, each drug vs its control) were: Remdesivir RR=0.95 (0.81-1.11, p=0.50; 301/2743 active vs 303/2708 control),
https://www.medrxiv.org/content/10.1101/2020.10.15.20209817v1