COVID-19: Examining the blood components of infected people: Technology for predicting aggravation
National Center for Global Health and Medicine:
The National Center for Global Health and Medicine has investigated the blood components of people infected with the new corona.
Predict whether it will become severe.
“Realization of inspection technology to detect people with severe illness at an early stage” is expected.
Changes in blood components and symptoms:
The group received regular blood donations from 28 COVID-19 patients.
Detailed analysis of “what is the relationship between blood components and changes in symptoms”.
Results of analysis:
12 patients with severe illness:
CCL17 protein levels were lower than normal from the early stages of infection.
Mild and moderate patients:
On the other hand, in people with mild or moderate illness, the value was about the same as usual.
Another 4 types of protein:
In addition, it was found that another four types of proteins “increased rapidly from a few days before they became severe.”
Prediction of aggravation: 5 types of proteins
COVID-19 patients “initially may be mild but suddenly become severe”
According to the group, “By examining the concentration of five types of proteins in the blood, it is possible to predict the severity of the disease.”
National Center for Global Health and Medicine:
The sooner you know who is becoming more severe, the faster you can be treated.
We would like to conduct further research and develop test kits in clinical settings.
NHK news
https://www3.nhk.or.jp/news/html/20200925/k10012633511000.html
Identification of humoral factors predicting the severity of COVID-19
National Center for Global Health and Medicine
Announcement points:
Patients with severe illness:
It was found that the CCL17 * 1 concentration in the blood of patients with COVID-19 that became severe or severe was below the standard value from the early stage of infection with the new coronavirus (SARS-CoV-2).
A few days before its aggravation:
It is clear that interferon lambda 3 (IFN-λ3 * 2), CXCL9 * 3, IP-10 * 4, and IL-6 * 5 show high values in patients who become severe or severe several days before the severity. became.
Enclosure of potentially severe patients:
Enclose patients who can become severe or severe with CCL17 levels in the early stages of infection.
It is thought that accurate treatment can be performed by detecting the timing of the subsequent onset of aggravation with IFN-λ3, CXCL9, IP-10, and IL-6.
National Center for Global Health and Medicine
http://www.ncgm.go.jp/pressrelease/2020/20200924.html
Charite University of Germany: Identification of blood biomarker candidates for predicting the severity of new corona
Germany: Charite-Universitatsmedizin Berlin
June 4, 2020
Together with the Francis Crick Institute in the UK, it announced that it has identified 27 proteins in the blood of COVID-19 patients with varying concentrations depending on their severity.
Using these biomarker profiles may help physicians predict disease progression and decide which treatment to take.
Details of the study were published in the online version of Cell Systems magazine on June 1, 2020.
Nikkei Biotech ONLINE
https://bio.nikkeibp.co.jp/atcl/news/p1/20/06/11/07072/