💉AIST: Understanding the mechanism of action and drug resistance of hepatitis B therapeutic drug with the help of AIDS virus

By AIST, 5 Science

💉AIST: Understanding the mechanism of action and drug resistance of hepatitis B therapeutic drug with the help of AIDS virus

– Modify the AIDS virus reverse transcriptase to resemble the hepatitis B virus reverse transcriptase –

point

  1. Analyze its three-dimensional structure by linking Entecavir with hepatitis B therapeutic drug to the modified AIDS virus reverse transcriptase
  2. Elucidate the mechanism by which entecavir binds to reverse transcriptase and the mechanism by which drug resistance develops
  3. Expect anticipated drug development acting on drug-resistant hepatitis B virus

This research result will be published online in the journal Scientific Reports on January 26, 2018 (UK time).

http://www.aist.go.jp/aist_j/press_release/pr2018/pr20180126/pr20180126.html

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