新型コロナウイルス感染症関連研究の
COVID-19: SPring-8 Supports Drug Discovery: Protein Crystal Analysis Beamline
COVID-19: SPring-8
April 7, 2020
Japan Synchrotron Radiation Research Institute: (JASRI)
The spread of the new coronavirus infection is currently spreading worldwide, and its analysis and overcoming is an urgent issue.
Research on this virus is ongoing worldwide.
In order to promptly overcome infectious diseases, we support “Drug discovery-related research using a protein crystal analysis beamline at the large synchrotron radiation facility SPring-8 * 1”.
Experiment contents and samples:
Research support for antiviral drug search and molecular design * 2:
New coronavirus (SARS-CoV-2),
New coronavirus-derived proteins / nucleic acids,
Crystal analysis of drug candidate substances
Is eligible.
Safety review:
Because it is performed with the same standard as before, it applies to biosafety level 1 * 3 samples.
Basically, automatic measurement or remote measurement after sending the sample to SPring-8.
For automatic measurement, anyone can easily use the structural analysis: “ZOO system (https://www.riken.jp/press/2019/20190207_1/)”.
Please contact us for details.
SPring-8 Web Site
http://www.spring8.or.jp/ja/news_publications/press_release/2020/200407/
Synchrotron radiation facility SPring-8: Corona drug discovery research specialization
Antiviral drugs:
In general, infection is prevented by blocking any of the invasion, proliferation, or release of cells.
The main role of the work is the proteins and nucleic acids that make up the virus.
The purpose of drug discovery research is to search for and design chemical substances that suppress its function.
Measure with SPring-8 / determine the three-dimensional structure of the molecule
Crystallized chemical substances such as proteins / nucleic acids
Measured with SPring-8,
Determine the three-dimensional structure of the molecule,
Useful for drug design.
From April 7, three beamlines will be opened only for research on antiviral drug discovery and molecular design.
Chemical Daily
https://www.chemicaldaily.co.jp/
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