RIKEN: Identify new genetic markers of atrial fibrillation by multidisciplinary analysis
The International Collaborative Research Group conducted GWAS on 65,446 people with atypical atrial fibrillation, including Japanese, and 500,000 controls, and found numerous new susceptibility loci of atrial fibrillation.
After that, omics analysis including transcriptome analysis of the left atrium was performed to identify 57 genes on which genetic polymorphisms at these sensitive loci act.
These gene groups are related to cardiac differentiation and electrophysiological functions, myocardial contraction and morphogenesis, and show the overall picture of the molecular mechanism of atrial fibrillation.
The results of this research will be published online in the international scientific journal “Nature Genetics” online (June 11, Japan time: June 12).
RIKEN
— Translated by TokioX’press —