Kyoto University: Cell sheet transplantation to the surface of the heart: Endoscopic device “ECSheeD”
Kyoto University:
November 20
Using an endoscopic method that uses a cell sheet with less burden
Announced that it has developed a device for transplantation on the surface of the heart.
The research results are published in “Regenerative Therapy”.
QLifePro Medical News
http://www.qlifepro.com/news/20201124/endoscopic-cell-sheet-transplantation.html
Development of cell sheet transplantation device on the surface of the heart
-Aiming for application to cardiac regenerative medicine-
Hidetoshi Masumoto Medical School Hospital
Hiroaki Nagata Doctoral student, Graduate School of Medicine,
Hideki Yamashita Ashimori Industry Co., Ltd.,
Shoji Uesugi Director, Nikke Medical
We have developed a device for implanting cell sheets onto the surface of the heart using a less burdensome endoscopic method.
iPS cell sheet transplantation:
In recent years, from human induced pluripotent stem cells (iPS cells), etc.
The cell sheet made,
Transplanted on the surface of the heart
For application in the treatment of heart failure,
Research on cardiac regenerative medicine is underway.
Conventional problems:
Currently, it is common practice to expose the heart and then attach a cell sheet by surgery to make an incision in the middle of the chest or between the ribs.
However, such surgery is
May cause complications such as wound infection
In addition, postoperative pain becomes stronger, etc.
It can increase the burden on the patient being treated.
This new development method:
This time, in the development of the endoscopic device, we used “a human body simulator for 3D print production using CT data of adult humans”.
We have established and verified a technique for transplanting cell sheets reliably and without distortion.
The application of this device is expected to popularize safe and low-burden cardiac regenerative medicine.
Endoscopic Cell Sheet delivery Device: (ECSheeD)
This device is named “Endoscopic Cell Sheet delivery Device” (ECSheeD).
By combining frames of two different thicknesses, we succeeded in “smoothly delivering the cell sheet part into the body.”
The results of this research were published in the international academic journal “Regenerative Therapy” on November 17, 2020.
Kyoto University
https://www.kyoto-u.ac.jp/ja/research/research_results/2020/201120_1.html