Professor Wataru Kamiya, Gunma University Graduate School, who artificially synthesized the new coronavirus = Photographed by Tetsuya Shoji at 2:00 pm on October 30, 2020 in Maebashi City
COVID-19: Gunma University succeeds in artificial synthesis of coronavirus: incorporated into BAC
-Reproduction of infection and elucidation of mechanism-
Gunma University Graduate School
Professor Wataru Kamiya (Virology):
Succeeded in artificial synthesis of the new coronavirus.
This will be useful for reproducing viral infections and elucidating about 30,000 bases of RNA (ribonucleic acid).
Intracellular replication of genetic information:
Professor Kamiya obtained the virus gene from the National Institute of Infectious Diseases.
He integrated into a bacterial artificial chromosome (BAC),
By replicating the genetic information inside the cell,
He artificially created a new type of coronavirus.
Comparison with SARS virus:
Comparison between the new coronavirus and “SARS virus, which is said to have the same gene of about 80%”.
It is known that “there is a clear difference in the length of the ORF3b gene involved in immune cell activation.”
Artificial synthesis leads to the elucidation of these individual genes.
Incorporates Green Fluorescent Protein (GFP):
In addition, if the gene is modified to incorporate green fluorescent protein (GFP) so that it emits light, visualization will be easier.
Professor Kamiya:
Synthetic viruses are the first tool to elucidate the new coronavirus.
“It is possible to reproduce the infection and proliferation and clarify the mechanism of pathogenicity and outbreak,” he said.
Mainichi newspaper
https://mainichi.jp/articles/20201105/k00/00m/040/044000c
MIT Tech Review: Accelerating “Research on Artificial Synthesis” of New Coronavirus
University of North Carolina:
This laboratory is trying to artificially synthesize a new type of coronavirus.
Professor Ralph Barrick:
The research team used the genetic code published online in January 2020 by the China Research Institute.
The genetic code of the new coronavirus
Read by computer,
Based only on that genetic code
Plans to artificially synthesize the new coronavirus.
Artificial synthesis of virus:
Companies that can “artificially synthesize” viruses based on genetic information
IDT (Integrated DNA Technology),
Twist Bioscience),
ATUM etc.
A company that synthesizes custom DNA molecules on a contract basis.
At the cost of thousands of dollars
Order the right gene and
Connect the genes together
Synthesize the coronavirus genome.
The virus can be restored by introducing the synthetic DNA into cells.
Blueprint of artificial synthetic virus:
For researchers, synthetic viruses are
An effective means of studying the increased toxicity of treatments, vaccines, and mutations.
It plays an important role in responding to sudden outbreaks.
Biologists rush to re-create the China coronavirus from its DNA code
University of North Carolina lab, there’s a different race.
Researchers
are trying to create a copy of the virus. From scratch. Led by Ralph Baric, an expert in coronaviruseswhich get their name from the crown-shaped spike they use to enter human cells
the North Carolina team
expects to recreate the virus starting only from computer readouts of its genetic sequence posted online by Chinese labs last month.The remarkable ability
to “boot up” viruses from genetic instructions is made possible by companies that manufacture custom DNA molecules, such asIntegrated DNA Technology,
Twist Bioscience,
and Atum.By ordering the right genes,
which cost a few thousand dollars, and then stitching them together to create a copy of the coronavirus genome,
it’s possible to inject the genetic material into cells and jump-start the virus to life.–
MIT Technology Review