TIT:PVA with BPA through reversible boronate esters in aqueous solution

By Cancer, disease, Medical science

TIT:PVA with BPA through reversible boronate esters in aqueous solution

Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism

Here, we report that poly(vinyl alcohol) (PVA) can form complexes with BPA through reversible boronate esters in aqueous solution,

and the complex termed PVA-BPA can be internalized into cancer cells through LAT1-mediated endocytosis, thereby enhancing cellular uptake and slowing the untoward efflux.

In vivo study, compared with clinically used fructose-BPA complexes, PVA-BPA exhibited efficient tumor accumulation and prolonged tumor retention with quick clearance from bloodstream and normal organs.

Ultimately, PVA-BPA showed critically enhanced antitumor activity in BNCT.

The facile technique proposed in this study offers an approach for drug delivery focusing on drug metabolism.

Science Advances

https://advances.sciencemag.org/content/6/4/eaaz1722

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