Osaka Univ: iPS cardiomyocyte sheet, directly attached to heart: World’s first successful operation
Osaka University: iPS cells
“Sheet heart muscle cells made from iPS cells in a sheet for patients with severe heart disease”
Osaka University: Professor Sawa Group:
On January 27, it was revealed that this operation had been performed for the first time.
The operation was successful and the patient moved to a general room on the morning of the 27th.
The patient suffered from ischemic cardiomyopathy and was difficult to recover from medical treatment with drugs.
This surgery:
It is being conducted as a “trial” to develop new treatments.
Over a year, safety and effectiveness were verified.
Nine more surgeries will be performed over the next three years.
What is a “cardiomyocyte sheet”:
“Cardiomyocyte sheet” was developed by Prof. Sawa’s group.
“Produced by culturing iPS cells provided by iPS Cell Research Institute of Kyoto University.”
One sheet: 4 to 5 cm in diameter, 0.1 mm thick
Three of these sheets: directly pasted and transplanted around the left ventricle,
Number of cells: 100 million cells in total
Efficacy of “cytokine”:
A type of protein called “cytokine” oozes out of the attached cell sheet.
“Cytokines” work by creating new blood vessels, which is expected to restore cardiac function.
NHK News