COVID-19: Preventive effect of AstraZeneca 1/5? : Korea Disease Control and Prevention Agency
-Amount of neutralizing antibody and infection prevention effect-
Korea Disease Control and Prevention Agency:
The research results of the National Institute of Health have recently been published.
AstraZeneca (AZ) in South Korea
The “neutralizing antibody titer” of the vaccinated person is
Compared to Pfizer and Moderna inoculators
It is said that it will be reduced to 1/5 and 1/7, respectively.
Comparison of neutralizing antibody titers:
So far
mRNA vaccine: Moderna and Pfizer vaccines,
Viral vector vaccine: From AZ and Janssen Pharma
It is said to produce more neutralizing antibodies.
There were research results overseas.
For the first time, we investigated the neutralizing antibody titers by vaccine in Korean inoculators.
AZ vaccine in Korea:
The AZ vaccine was first introduced in South Korea and inoculated about 11 million people.
Expert opinion:
Experts are in a position that it is difficult to judge the effect of the vaccine only by the value of neutralizing antibody.
Analysis of antibody titers by vaccine:
Disease Agency National Institute of Health
Interim results of immunogenicity analysis of new corona vaccinated individuals
On November 17, the materials of the Central Epidemic Prevention Headquarters were released.
Central Epidemic Prevention Headquarters
Try to shorten the booster vaccination interval from 6 months after completion to 4-5 months.
This research material was presented as one of the grounds.
-Results of analysis of sustainability of antibody formation by vaccine-
According to the analysis results of 969 people in the new corona vaccination group in South Korea aged 20 to 59 years old.
-Maximum neutralizing antibody titer after inoculation is completed-
Moderna is the highest at 2852,
AZ Pfizer cross inoculation (2368),
Pfizer (2119),
AZ (392),
Janssen was inoculated only once (263) in that order.
Only this neutralizing antibody titer was compared.
AZ is only 13% and 18%, respectively, compared to Moderna and Pfizer.
Gachon University School of Medicine
Professor Jung Jae-hoon (Department of Preventive Medicine)
Just because the antibody is low
It ’s not that it does n’t prevent infection.
It may be effective.
It is difficult to directly link the neutralizing antibody titer with the infection-preventing effect.
Longer data are needed to prove the difference in efficacy by vaccine.
-Korea will not introduce AZ next year-
The new corona vaccination response promotion team will end AZ vaccination by the end of the year.
“There are no plans to purchase additional vaccines for AZ and Janssen,” he said.
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