COVID-19：强制性卡介苗接种的抑制作用：京都大学，经统计验证
京都大学：心脏未来研究中心
北山忍（Shinobu Kitayama）教授：密歇根大学教授
8月20日，宣布“强制性BCG疫苗接种可能会导致新冠状病毒传播的减少”。
该关系尚不清楚，已得到统计验证。
结果，可以推断BCG的大规模接种将在将来抑制新的电晕。
比较来自130个国家/地区的数据：
大约有130个国家/地区拥有新的电晕流行的前30天的数据。
对需要在2000年之前接种卡介苗的国家与未进行卡介苗接种的国家进行了比较。
我们着眼于一定时期内的增长率，以消除每个国家感染报告中偏见的影响。
比较分析结果：
感染者和死亡者的增长率为
BCG授权国家/地区的增长率明显较低，与前15天一样。
推测该结果为“多数BCG接种引起的集体免疫的效果，仅对个体接种BCG不能期待较大的效果”。
日刊工业新闻
https://www.nikkan.co.jp/articles/view/00568630
Mandated Bacillus Calmette-Guérin (BCG) vaccination predicts flattened curves for the spread of COVID-19
Martha K. Berg*, Qinggang Yu, Cristina E. Salvador, Irene Melani, Shinobu Kitayama*
Science Advances 05 Aug 2020:
Vol. 6, no. 32, eabc1463
DOI: 10.1126/sciadv.abc1463
Abstract
Bacillus Calmette-Guérin (BCG) vaccination
may reduce the risk of a range of infectious diseases, and if so, it could protect against coronavirus disease 2019 (COVID-19).
mandated BCG vaccination until 2000
Here, we compared countries that mandated BCG vaccination until at least 2000 with countries that did not.
the rate of the day-by-day increase
To minimize any systematic effects of reporting biases, we analyzed the rate of the day-by-day increase in both confirmed cases (134 countries) and deaths (135 countries) in the first 30-day period of country-wise outbreaks.
The 30-day window was adjusted to begin at the country-wise onset of the pandemic.
Linear mixed models
revealed a significant effect of mandated BCG policies on the growth rate of both cases and deaths after controlling for median age, gross domestic product per capita, population density, population size, net migration rate, and various cultural dimensions (e.g., individualism).
Our analysis suggests that mandated BCG vaccination can be effective in the fight against COVID-19.
https://advances.sciencemag.org/content/6/32/eabc1463.full
BCG-induced trained immunity: can it offer protection against COVID-19? | Nature Reviews Immunology