东北大学：ALS，经人类骨髓源Muse细胞处理：对模型小鼠给药
2020年11月2日
重新测试结果：
【总览】
东北大学：Mari Dezawa教授
冈山大学：安倍浩二教授，山下彻教授
合作研究小组：
将人骨髓来源的Muse细胞静脉内施用至肌肉萎缩性侧索硬化（ALS）模型小鼠。
之后，我发现它具有抑制运动功能症状进展的作用。
科学报告：
这些研究结果于10月13日作为研究文章发表在英国科学杂志“ Scientific Reports”上。
什么是ALS：
ALS是一种难治的神经系统疾病，其大脑和脊髓中的运动神经细胞数量减少，继而运动麻痹。
当前的情况是，没有根本的待遇。
人骨髓来源的Muse细胞：
这次，人静脉来源的Muse细胞被重复静脉内施用。
迁移到小鼠脊髓（严重受伤的腰脊髓），
分化成组成脊髓的细胞
抑制运动神经细胞丢失和运动功能下降，
我能够确认治疗效果。
研究结果：
有望导致开发新的治疗方法，以“挽救患有进行性运动麻痹和呼吸肌麻痹的ALS患者”。
新闻发布/研究结果
东北大学
https://www.tohoku.ac.jp/japanese/2020/11/press20201102-01-als.html
Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis
Toru Yamashita, Yoshihiro Kushida, […]Koji Abe Scientific Reports volume 10, Article number: 17102 (2020)
Cite this article
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Abstract
Amyotrophic lateral sclerosis (ALS)
is a fatal neurodegenerative disease characterized by progressive motor neuron loss.
Muse cells
are endogenous reparative pluripotent-like stem cells distributed in various tissues.
They can selectively home to damaged sites after intravenous injection by sensing sphingosine-1-phosphate produced by damaged cells, then exert pleiotropic effects, including tissue protection and spontaneous differentiation into tissue-constituent cells.
In G93A-transgenic ALS mice, intravenous injection of 5.0 × 104 cells
revealed successful homing of human-Muse cells to the lumbar spinal cords, mainly at the pia-mater and underneath white matter, and exhibited glia-like morphology and GFAP expression.
In contrast, such homing or differentiation were not recognized in human mesenchymal stem cells but were instead distributed mainly in the lung.
Relative to the vehicle groups,
the Muse groupsignificantly improved scores in the rotarod, hanging-wire and muscle strength of lower limbs, recovered the number of motor neurons, and alleviated denervation and myofiber atrophy in lower limb muscles.
These results suggest that
Muse cells homed in a lesion site-dependent manner and protected the spinal cord against motor neuron death.
Muse cells might also be a promising cell source for the treatment of ALS patients. Scientific Reports